Lasgrain 100mg Tablet 4pcs

Uses of Lasgrain 100mg Tablet

• Treatment of Migraine

How does Lasgrain 100mg Tablet work?

Side Effects of Lasgrain 100mg Tablet

Dizziness, Fatigue, Paresthesia (tingling or pricking sensation), Sedation

Quick Suggestions:

• Tell your doctor and pharmacist if you are allergic to Lasmiditan, any other medications, or any of the ingredients in Lasmiditan.
• Tell your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking.
• Tell your doctor if you have or have ever had high blood pressure; slow, weak, or irregular heartbeat; or liver problems.
• Follow the directions on your prescription carefully.

Indication of Lasgrain 100mg Tablet

Lasgrain 100 is a medication used to treat acute migraine attacks by improving blood flow in the brain and preventing muscle activity that triggers migraines. It effectively reduces the intensity and frequency of migraines, helping to enhance daily life and overall well-being.

Who is Affected by Migraines?

• Common Age Group: Typically affects adults aged 30 to 40.
• Gender: Both men and women, but more commonly seen in women.
• Involved Areas:
  • Brain
  • Blood vessels
  • Neurons

Mimicking Conditions

• Tension-type headache
• Cluster headache
• Cerebral aneurysms
• Chronic paroxysmal hemicrania
• Dissection syndromes
• Encephalitis
• Subarachnoid/intracranial hemorrhage
• Meningitis
• Temporal/giant cell arteritis

Necessary Health Tests

• CT Scan (Head): To rule out other conditions.
• MRI: To rule out other potential causes.

Treatment Options for Migraine

• NSAIDs: Aspirin, Diclofenac, Ibuprofen.
• Triptans: Sumatriptan, Zolmitriptan, Naratriptan.
• Ergotamines: Ergotamine, combinations like Caffeine+Ergotamine+Paracetamol+Prochlorperazine.
• Antiemetics: Metoclopramide, Prochlorperazine.
• CGRP Antagonists: Erenumab, Fremanezumab.
• Lasmiditan
• Beta Blockers: Propranolol, Metoprolol.
• Antidepressants: Amitriptyline, Fluoxetine.
• Antiepileptics: Topiramate, Sodium valproate.
• Calcium Channel Blockers: Flunarizine, Verapamil.

Consult Specialists

• General Physician
• Neurologist

Pharmacology

Migraines were traditionally treated by constricting blood vessels, as dilation during migraines was linked to pain. However, the neurogenic hypothesis suggests that nerve activity, rather than blood vessel dilation, is the main contributor to migraine pain.
Lasmiditan, the active ingredient in Lasgrain, likely works by activating 5-HT1F receptors, reducing nerve activity linked to migraines. It selectively targets these receptors and does not affect other 5-HT or monoamine receptors.

Dosage & Administration of Lasgrain 100mg Tablet

The recommended oral dose of Lasgrain is 50 mg, 100 mg, or 200 mg, taken as needed. Only one dose should be taken in 24 hours, and the patient must wait at least 8 hours after taking it before driving or operating machinery. A second dose has not been proven effective for the same migraine attack.

• Pediatric Use: Not established.
• Hepatic Impairment: No adjustment is needed for mild/moderate impairment; not recommended for severe impairment.

Interaction

• CNS Depressants: Lasgrain can cause sedation. Caution is advised when combined with alcohol or CNS depressants.
• Serotonergic Drugs: Combining Lasgrain with serotonergic drugs (e.g., SSRIs, and MAOIs) can increase the risk of serotonin syndrome.
• Heart Rate Lowering Drugs: Caution when used with drugs that lower heart rate, such as Lasgrain, may further decrease heart rate.
• P-gp and BCRP Substrates: Avoid using Lasgrain with drugs that are P-gp or BCRP substrates.

Contraindications

Hypersensitivity

Pregnancy & Lactation

There is limited data on the effects of Lasmiditan in pregnant or breastfeeding women. It is excreted into rat milk, so caution is advised. Weigh the benefits of breastfeeding against potential risks to the infant.

Precautions & Warnings

• Avoid driving or operating machinery for at least 8 hours after taking a dose.
• Use caution with CNS depressants and alcohol.
• Stop use if symptoms occur.
• Detoxification may be needed.

Storage:

Store below 30°C, away from light and moisture. Keep out of reach of children.